Scratchova potraga za odbjeglim žirom ovoga puta će ga katapultirati u svemir, gdje će se dogoditi niz kozmičkih događaja koji prijete uništenju cijelog svijeta. Kako bi se spasili od katastrofe koja im prijeti, Manny, Sid i Diego, morat će napustiti svoj dom i krenuti u nove avanture te putovanje u nove, egzotične zemlje gdje će upoznati mnoštvo novih likova.
Seven years ago, a meteorite struck the Shibuya district of Tokyo. Alien lifeforms known as the Worms, emerged from the meteorite and became a threat to humanity. Ever since, Souji Tendou has been training while waiting for the Kabuto Zecter so that he may properly take up the mantle of Kamen Rider Kabuto. Making many enemies while at the same time meeting other Riders with mysterious origins, Tendou attempts to accomplish his goal at all costs: to destroy all Worms that threaten humanity.
