Tom, famous baritone Signor Thomasino Catti-Cazzaza, enthralls a concert audience with his rendition of "Largo al factotum", from Rossini's "Il Barbiere di Siviglia", while Jerry strives for sleep under the stage.
Jerry mixes and drinks a high-acceleration potion which renders him so fast that he eats all of Tom's food before the bewildered cat can even see him.
Jerry's mouse hole connects two homes, with Tom living in one residence, a neighboring cat in the other. Jerry decides the best survival plan is pitting the cats against each other, without their knowledge.
Tom and Jerry are on a building construction site. Things explode, Tom loses his fur for a while, Jerry hides in a glove, Tom falls from a great height, and Tom has great trouble with a rock-and-girder see-saw.
Jerry orders a vicious dog from a catalog, but when it arrives, it's even smaller than Jerry. However, despite its size, it launches an impressive attack on Tom
Tom enjoys the role of top cat until an adorable red-and-white-haired kitten is brought into the house of a young blonde woman.
Waif mouse Jerry, encrusted with snow, peers through a warmly lit window at Tom asleep by the fire in a room full of cheese.
Jerry uses a robot mouse to snatch a sample from a lunar cheese mine being mined by robots; Tom gives chase with a robot cat.
Tom chases Jerry through city streets, gets run over by a streetcar (twice), and follows Jerry into a department store. In the toy department, they have some fun with radio-controlled cars and a collection of mouse dolls. They move on to sporting goods, where Jerry manages to combine table tennis with croquet.
Tom chases Jerry around a pool hall. Jerry's fairy godmouse arrives, and Jerry tells the story; she gives him an invisibility potion. Jerry uses this to do some creative barbering on Tom, but when the potion wears off, Tom gets his revenge, and they both have a good laugh.
When a bulldog tells Jerry to "just whistle" any time that he needs him, Tom's in for big trouble until he puts earmuffs on the mutt.
Jerry, with the help of a mouse friend, is lowered on a fishing line, abuses the sleeping Tom in various ways, and is yanked away before Tom sees him. First, he hits Tom with a fireplace shovel and plants it in Tom's hand; next, he puts a gun in Tom's hand and pulls the trigger; he puts a noose around Tom's neck; positions a ketchup-covered knife (complete with ketchup "wound"); and finally puts Tom into an archery bow. Tom finally gets his revenge,
Essentially one long chase scene, in an urban setting; at the end, a dog joins in, to Jerry's annoyance.
2565 AD. Tom and Jerry are once again manipulating robot versions of themselves in space. Tom experiments with invisibility, a giant electromagnet, and explosives, with results from bad to disastrous.
